BioTEL Publications

Underlined: Current BioTEL member


60. Marina Franca Dias, Kwangsic Joo, Jessica Kemp, Silvia Ligório Fialho, Armando da Silva Cunha Jr., Se Joon Woo, and Young Jik Kwon. “Molecular Genetics and Emerging Therapies for Retinitis Pigmentosa: Basic Research and Clinical Perspectives”. Progress in Retinal Eye Research (2017).



59. Xingyi Ma, June Huh, Wounjhang Park, Luke P. Lee, Young Jik Kwon, and Sang Jun Sim. “Gold nanocrystals with DNA-directed morphologies.” Nature communications 7:12873 (2016).

58. Julius A. EdsonYoung Jik Kwon. “Design, challenge, and promise of stimuli-responsive nanoantibiotics.” Nanoconvergence 3:26 (2016). (Invited Review)

57. Dominique Ingato, Jong Uk Lee, Sang Jun Sim, and Young Jik Kwon. “Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery.” Journal of Controlled Release 241, 174-185. (2016)

56. Cheol Am Hong, Soo Kyung Cho, Julius A. Edson, Jane Kim, Dominique Ingato, Bryan Pham, Anthony Chuang, David Fruman, Young Jik Kwon. “Viral/Nonviral Chimeric Nanoparticles to Synergistically Suppress Leukemia Proliferation via Simultaneous Gene Transduction and Silencing.” ACS Nano 10:9, 8705-8714. (2016). (Cover article)

55. Xingyi Ma, June Huh, Wounjhang Park, Luke P. Lee, Young Jik Kwon, Sang Jun Sim. Gold nanocrystals with DNA-directed morphologies. Nature Communications 7, 12873 (2016).

54. Mohammad M. Al-Sanea, Ahmed Z. Abdelazem, Byung Sun Park, Kyung Ho Yoo, Taebo Sim, Young Jik Kwon, So Ha Lee. “ROS1 Kinase Inhibitors for Molecular-Targeted Therapies.” Current Medicinal Chemistry 23, 142-160 (2016)

53. Yi Xi Wu and Young Jik Kwon. “Aptamers: The “evolution” of SELEX.” Methods 106, 21-28. (2016).

52. Chan Yeong Heo and Young Jik Kwon. “Killing two birds or more with one stone.” Advanced drug delivery reviews 98, 1 (2016).

51. Jessica A. Kemp, Min Suk Shim, Chan Yeong Heo, Young Jik Kwon. “Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy. Advanced drug delivery reviews 98, 3-18 (2016).



50. Minjeong Jang, Young Jik Kwon, and Nae Yoon Lee. “Non-photolithographic plastic-mold-based fabrication of cylindrical and multi-tiered poly (dimethylsiloxane) microchannels for biomimetic lab-on-a-chip applications.” RSC Advances 5.122 : 100905-100911 (2015).

49. Soo Kyung Cho, Chris Dang, Xi Wang, Regina Ragan, Young Jik Kwon*. Mixing-sequence-dependent nucleic acid complexation and gene transfer efficiency by polyethylenimine. Biomaterials Science 3, 1124-1133(2015).

48. Shirley Wong, Young Jik Kwon*. Facile synthesis of high-molecular-weight acid-labile polypeptides using urethane derivatives. Journal of Polymer Science A: Polymer Chemistry 53, 280-286 (2015)  (invited contribution).



47. Genesis Zamora, Frederick Wang, Chung-Ho Sun, Anthony Trinidad, Young Jik Kwon, Soo Kyung Cho, Kristian Berg, Steen Madsen, Henry Hirschberg*. Photochemical internalization mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier. Journal of Biomedical Optics 19, 105009 (2014).

46. Julius A. EdsonYoung Jik Kwon*. RNAi for silencing drug resistance in microbes toward development of nanoantibiotics. Journal of Controlled Release 189, 150-157 (2014)

45. Frederick Wang*, Genesis Zamora, Chung-Ho Sun, Anthony Trinidad, Changho ChunYoung Jik Kwon, Kristian Berg, Steen J. Madsen, Henry Hirschberg. Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene. Journal of Neurooncology 118, 29-37 (2014)

44. Shirley Wong, Min Suk Shim, Young Jik Kwon*. Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications. Journal of Materials Chemistry B2(6), 595-615 (2014) (Invited review) (Cover Article)

43. Min Suk Shim, Seong-Sil Chang, Young Jik Kwon*. Stimuli-responsive siRNA carriers for efficient gene silencing in tumors via systemic delivery. Biomaterials Science2(1), 35-40 (2014)



42. Jessica Kemp, Julius Edson, Young Jik Kwon*. Nanoantibiotics: Nanotechnology in fighting against infectious diseases. Frontiers of Nanobiomedical Research – Vol II, edited by V. Torchilin  (Invited book chapter)

41.  Soo Kyung Cho, Ali Pedram, Ellis R. Levin*, Young Jik Kwon*. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials34(38), 10228-10237 (2013)

40. Chang Soo Kim, Wenjuan Qi, Jun Zhang, Young Jik Kwon*, Zhongping Chen*. Imaging and quantifying Brownian motion of micro- and nanoparticles using phase resolved Doppler variance optical coherence tomograph. Journal of Biomedical Optics 18, 030504 (2013)

39. Min Sun Song, Seung Phill Choi, Young Jik Kwon, Sang Jun Sim*. Real time, sensitive, and specific detection of promoter-polymerase interactions in gene transcription using a nanoplasmonic sensor. Advanced Materials 25, 1265-1269 (2013) (Cover article)



38. Soo Kyung ChoYoung Jik Kwon*.Synthetically engineered viruses: Can synthetic chemistry tame the nature? Current Opinion in Solid State & Materials Science 16, 276-286 (2012) (Invited review).

37. Marlon Mathews*, En-Chung Shih, Genesis Zamora, Chnung-Ho Sun, Soo Kyung ChoYoung Jik Kwon, Henry Hirschberg. Glioma cell growth inhibition following photochemical internalization enhanced PTEN gene transfection. Lasers in Surgery and Medicine 44, 746-754 (2012)

36. Min Suk Shim, Young Jik Kwon*. Ketalized poly(amino ester) for stimuli-responsive and biocompatible gene delivery. Polymer Chemistry 3, 2570-2577 (2012).

35. Min Suk Shim, Shirley WongYoung Jik Kwon*. siRNA as a conventional drug in the clinic? Challenges and Current Technologies. Drug Discovery Today Technologies 9, 167-173 (2012) (Invited review).

34. Min Suk ShimYoung Jik Kwon*. Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Advanced Drug Delivery Reviews 64, 1046-1059 (2012) (Invited review).

33. Young Jik Kwon*. Before and after endosomal escape: Roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Accounts of Chemical Research 45, 1077-1088 (2012) (Invited review).

32. Soo Kyung ChoYoung Jik Kwon*. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials 33, 3316-3323 (2012).



31. Ae Jung HuhYoung Jik Kwon*. “Nanoantibiotics’: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. Journal of Controlled Release 156, 128-145 (2011). (One of the most downloaded articles October 2011-)

30. Soo Kyung ChoYoung Jik Kwon*. Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectors. Journal of Controlled Release 150, 287-297 (2011).

29.  Min Suk ShimYoung Jik Kwon*. Dual mode polyspermine with tunable degradability for plasmid DNA and siRNA delivery. Biomaterials 32, 4009-4020 (2011).

28. Shirley WongYoung Jik Kwon*. Synthetically functionalized retroviruses produced from the bioorthogonally engineered cell surface. Bioconjugate Chemistry 22, 151-155 (2011).



27. Min Suk ShimYoung Jik Kwon*. Efficient and targeted delivery of siRNA in vivo. FEBS Journal 277, 4814-4827 (2010) (Invited review).

26. Min Suk Shim, Xi Wang, Regina Ragan, Young Jik Kwon*. Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy. Microscopy Research and Technique 73, 845-856 (2010).

25. Chang Soo Kim, Yeh-Chan Ahn, Petra Wilder-Smith, Seajin Oh, Zhongping Chen*, Young Jik Kwon*. Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography. Biomedical Optics Express 1, 106-113 (2010).

24. Min Suk ShimChang Soo Kim, Yeh-Chan Ahn, Zhongping Chen, Young Jik Kwon*. Combined multi-modal optical imaging and targeted gene silencing using stimuli-transforming nanotheragnostics. Journal of the American Chemical Society  132, 8316-8324 (2010).

23. Yoon Kyung KimYoung Jik Kwon*. Separation and recovery of nucleic acids with improved biological activity by acid-degradable polyacrylamide gel electrophoresis. Electrophoresis 31, 1656-1661 (2010).

22. Min Suk ShimYoung Jik Kwon*. Acid-transforming polypeptide micelles as efficient, biocompatible, and versatile nonviral gene carriers. Biomaterials 31, 3404-3413 (2010).


21. Yoon Kyung KimYoung Jik Kwon*. Isolation of intact proteins from acid-degradable polyacrylamide gel. Proteomics 9, 3765-3771 (2009).(Highlighted article by the editor).

20. Chang Soo Kim, Petra Wilder-Smith, Yeh-Chan Ahn, Lih-Huei Liaw, Zhongping Chen*, Young Jik Kwon*. Enhanced detection of early stage oral cancer in vivo by optical coherence tomorgraphy using multi-modal delivery of gold nanoparticles. Journal of Biomedical Optics 14, 034008 (2009).

19. Min Suk ShimYoung Jik Kwon*. Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery. Bioconjugate Chemistry 20, 488-499 (2009).

18. Min Suk ShimYoung Jik Kwon*. Controlled cytoplasmic and nuclear localization of plasmid DNA and siRNA by differentially tailored polyethylenimine. Journal of Controlled Release 133, 206-213 (2009).


17. Young Jik Kwon*, Ching-An Peng. Differential interaction of retroviral vector with target cell: Quantitative effect of cellular receptor, soluble proteoglycan, and cell type on gene delivery efficiency. Tissue Engineering 14, 1497-1506 (2008) (invited paper).

16. In Kap Ko, Assem Ziady, Shwei LuYoung Jik Kwon*. Acid-degradable cationic methacrylamide polymerized in the presence of plasmid DNA as tunable non-viral gene carrier. Biomaterials 29, 3872-3881 (2008).

15. Min Suk ShimYoung Jik Kwon*. Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules 9, 444-455 (2008). (The 2nd most accessed article in the journal for the first quarter of 2008).

14.  Hong Yu*, Young Jik Kwon. Preparation and quantification of pseudotyped retroviral vector. Methods in Molecular Biology 433, 1-16 (2008). (Invited book chapter)

Before UCI (2001-2007)

13. Stephany M. Standley, Ines Mende, Sarah L. Goh, Young Jik Kwon, Tristan Beaudette, Edgar G. Engleman, Jean M. J. Fréchet*. Incorporation of CpG oligonucleotide ligand into protein-loaded particlevaccines promotes antigen-specific CD8 T cell immunity. Bioconjugate Chemistry 18, 77-83 (2007).

12. Young Jik Kwon, Edward James, Nilabh Shastri, Jean M. J. Fréchet*. In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.Proceedings of the National Academy of Sciences in the United States of America 102, 18264-18268 (2005).

11. Young Jik Kwon, Stephany M. Standley, Sarah L. Goh, Jean M. J. Fréchet*. Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles. Journal of Controlled Release 105, 199-212 (2005).

10. Young Jik Kwon, Ching-An Peng*. High-yield retroviral production using temperature modulated two-stage operation. Biotechnology and Bioengineering 90, 365-372 (2005).

9. Young Jik Kwon, Stephany M. Standley, Andrew P. Goodwin, Elizabeth R. Gillies, Jean M. J. Fréchet*. Directed antigen presentation using polymeric microparticulate carriers degradable at lysosomal pH for controlled immune responses. Molecular Pharmaceutics 2, 83-91 (2005).

8. Stephany M. Standley, Young Jik Kwon, Niren Murthy, Jun Kunisawa, Nilabh Shastri, Jean M. J. Fréchet*. Acid-Degradable Particles for protein-based vaccines: Enhanced survival rate for tumor-challenged mice using ovalbumin model. Bioconjugate Chemistry 15, 1281-1288 (2004).

7. Young Jik Kwon, Gene Hung, W. French Anderson, Ching-An Peng, Hong Yu*. Determination of Infectious retrovirus concentration from colony-forming assay with quantitative analysis. Journal of Virology 77, 5712-5720 (2003).

6. Young Jik Kwon, Ching-An Peng*. Evaluation of retroviral production systems using quantitative analysis. Biotechnology Progress 19, 528-537 (2003).

5. Young Jik Kwon, Ching-An Peng*. Calcium-alginate gel bead crosslinked with gelatin as potential microcarrier for anchorage-dependent cell culture. BioTechniques 33, 212-218 (2002) (Selected as a BioSpotlight of the issue).

4. Young Jik Kwon, Ching-An Peng*. Engineering analysis of ex vivo retroviral transduction systems. Annals of Biomedical Engineering 30, 731-742 (2002).

3. Young Jik Kwon, Ching-An Peng*. Transduction rate constant as more reliable index quantifying efficiency of retroviral gene delivery. Biotechnology and Bioengineering 77, 668-677 (2002).

2. Young Jik Kwon, Ching-An Peng*. Impact of cell growth morphology on retroviral transduction: Effect of contact inhibition. Biotechnology Progress 17, 240-246 (2001).

1. Young Jik Kwon, Hong Yu, Ching-An Peng*. Enhanced retroviral transduction of 293 cells cultured on liquid-liquid interface. Biotechnology and Bioengineering 72, 331-338 (2001)