BioTEL Publications

Underlined: Current BioTEL member


59. Xingyi Ma, June Huh, Wounjhang Park, Luke P. Lee, Young Jik Kwon, and Sang Jun Sim. “Gold nanocrystals with DNA-directed morphologies.” Nature communications 7:12873 (2016).

58. Julius A. EdsonYoung Jik Kwon. “Design, challenge, and promise of stimuli-responsive nanoantibiotics.” Nanoconvergence 3:26 (2016). (Invited Review)

57. Dominique Ingato, Jong Uk Lee, Sang Jun Sim, and Young Jik Kwon. “Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery.” Journal of Controlled Release 241, 174-185. (2016)

56. Cheol Am Hong, Soo Kyung Cho, Julius A. Edson, Jane Kim, Dominique Ingato, Bryan Pham, Anthony Chuang, David Fruman, Young Jik Kwon. “Viral/Nonviral Chimeric Nanoparticles to Synergistically Suppress Leukemia Proliferation via Simultaneous Gene Transduction and Silencing.” ACS Nano 10:9, 8705-8714. (2016). (Cover article)

55. Xingyi Ma, June Huh, Wounjhang Park, Luke P. Lee, Young Jik Kwon, Sang Jun Sim. Gold nanocrystals with DNA-directed morphologies. Nature Communications 7, 12873 (2016).

54. Mohammad M. Al-Sanea, Ahmed Z. Abdelazem, Byung Sun Park, Kyung Ho Yoo, Taebo Sim, Young Jik Kwon, So Ha Lee. “ROS1 Kinase Inhibitors for Molecular-Targeted Therapies.” Current Medicinal Chemistry 23, 142-160 (2016)

53. Yi Xi Wu and Young Jik Kwon. “Aptamers: The “evolution” of SELEX.” Methods 106, 21-28. (2016).

52. Chan Yeong Heo and Young Jik Kwon. “Killing two birds or more with one stone.” Advanced drug delivery reviews 98, 1 (2016).

51. Jessica A. Kemp, Min Suk Shim, Chan Yeong Heo, Young Jik Kwon. “Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy. Advanced drug delivery reviews 98, 3-18 (2016).



50. Minjeong Jang, Young Jik Kwon, and Nae Yoon Lee. “Non-photolithographic plastic-mold-based fabrication of cylindrical and multi-tiered poly (dimethylsiloxane) microchannels for biomimetic lab-on-a-chip applications.” RSC Advances 5.122 : 100905-100911 (2015).

49. Soo Kyung Cho, Chris Dang, Xi Wang, Regina Ragan, Young Jik Kwon*. Mixing-sequence-dependent nucleic acid complexation and gene transfer efficiency by polyethylenimine. Biomaterials Science 3, 1124-1133(2015).

48. Shirley Wong, Young Jik Kwon*. Facile synthesis of high-molecular-weight acid-labile polypeptides using urethane derivatives. Journal of Polymer Science A: Polymer Chemistry 53, 280-286 (2015)  (invited contribution).



47. Genesis Zamora, Frederick Wang, Chung-Ho Sun, Anthony Trinidad, Young Jik Kwon, Soo Kyung Cho, Kristian Berg, Steen Madsen, Henry Hirschberg*. Photochemical internalization mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier. Journal of Biomedical Optics 19, 105009 (2014).

46. Julius A. EdsonYoung Jik Kwon*. RNAi for silencing drug resistance in microbes toward development of nanoantibiotics. Journal of Controlled Release 189, 150-157 (2014)

45. Frederick Wang*, Genesis Zamora, Chung-Ho Sun, Anthony Trinidad, Changho ChunYoung Jik Kwon, Kristian Berg, Steen J. Madsen, Henry Hirschberg. Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene. Journal of Neurooncology 118, 29-37 (2014)

44. Shirley Wong, Min Suk Shim, Young Jik Kwon*. Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications. Journal of Materials Chemistry B2(6), 595-615 (2014) (Invited review) (Cover Article)

43. Min Suk Shim, Seong-Sil Chang, Young Jik Kwon*. Stimuli-responsive siRNA carriers for efficient gene silencing in tumors via systemic delivery. Biomaterials Science2(1), 35-40 (2014)



42. Jessica Kemp, Julius Edson, Young Jik Kwon*. Nanoantibiotics: Nanotechnology in fighting against infectious diseases. Frontiers of Nanobiomedical Research – Vol II, edited by V. Torchilin  (Invited book chapter)

41.  Soo Kyung Cho, Ali Pedram, Ellis R. Levin*, Young Jik Kwon*. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials34(38), 10228-10237 (2013)

40. Chang Soo Kim, Wenjuan Qi, Jun Zhang, Young Jik Kwon*, Zhongping Chen*. Imaging and quantifying Brownian motion of micro- and nanoparticles using phase resolved Doppler variance optical coherence tomograph. Journal of Biomedical Optics 18, 030504 (2013)

39. Min Sun Song, Seung Phill Choi, Young Jik Kwon, Sang Jun Sim*. Real time, sensitive, and specific detection of promoter-polymerase interactions in gene transcription using a nanoplasmonic sensor. Advanced Materials 25, 1265-1269 (2013) (Cover article)



38. Soo Kyung ChoYoung Jik Kwon*.Synthetically engineered viruses: Can synthetic chemistry tame the nature? Current Opinion in Solid State & Materials Science 16, 276-286 (2012) (Invited review).

37. Marlon Mathews*, En-Chung Shih, Genesis Zamora, Chnung-Ho Sun, Soo Kyung ChoYoung Jik Kwon, Henry Hirschberg. Glioma cell growth inhibition following photochemical internalization enhanced PTEN gene transfection. Lasers in Surgery and Medicine 44, 746-754 (2012)

36. Min Suk Shim, Young Jik Kwon*. Ketalized poly(amino ester) for stimuli-responsive and biocompatible gene delivery. Polymer Chemistry 3, 2570-2577 (2012).

35. Min Suk Shim, Shirley WongYoung Jik Kwon*. siRNA as a conventional drug in the clinic? Challenges and Current Technologies. Drug Discovery Today Technologies 9, 167-173 (2012) (Invited review).

34. Min Suk ShimYoung Jik Kwon*. Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Advanced Drug Delivery Reviews 64, 1046-1059 (2012) (Invited review).

33. Young Jik Kwon*. Before and after endosomal escape: Roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Accounts of Chemical Research 45, 1077-1088 (2012) (Invited review).

32. Soo Kyung ChoYoung Jik Kwon*. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials 33, 3316-3323 (2012).



31. Ae Jung HuhYoung Jik Kwon*. “Nanoantibiotics’: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. Journal of Controlled Release 156, 128-145 (2011). (One of the most downloaded articles October 2011-)

30. Soo Kyung ChoYoung Jik Kwon*. Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectors. Journal of Controlled Release 150, 287-297 (2011).

29.  Min Suk ShimYoung Jik Kwon*. Dual mode polyspermine with tunable degradability for plasmid DNA and siRNA delivery. Biomaterials 32, 4009-4020 (2011).

28. Shirley WongYoung Jik Kwon*. Synthetically functionalized retroviruses produced from the bioorthogonally engineered cell surface. Bioconjugate Chemistry 22, 151-155 (2011).



27. Min Suk ShimYoung Jik Kwon*. Efficient and targeted delivery of siRNA in vivo. FEBS Journal 277, 4814-4827 (2010) (Invited review).

26. Min Suk Shim, Xi Wang, Regina Ragan, Young Jik Kwon*. Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy. Microscopy Research and Technique 73, 845-856 (2010).

25. Chang Soo Kim, Yeh-Chan Ahn, Petra Wilder-Smith, Seajin Oh, Zhongping Chen*, Young Jik Kwon*. Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography. Biomedical Optics Express 1, 106-113 (2010).

24. Min Suk ShimChang Soo Kim, Yeh-Chan Ahn, Zhongping Chen, Young Jik Kwon*. Combined multi-modal optical imaging and targeted gene silencing using stimuli-transforming nanotheragnostics. Journal of the American Chemical Society  132, 8316-8324 (2010).

23. Yoon Kyung KimYoung Jik Kwon*. Separation and recovery of nucleic acids with improved biological activity by acid-degradable polyacrylamide gel electrophoresis. Electrophoresis 31, 1656-1661 (2010).

22. Min Suk ShimYoung Jik Kwon*. Acid-transforming polypeptide micelles as efficient, biocompatible, and versatile nonviral gene carriers. Biomaterials 31, 3404-3413 (2010).


21. Yoon Kyung KimYoung Jik Kwon*. Isolation of intact proteins from acid-degradable polyacrylamide gel. Proteomics 9, 3765-3771 (2009).(Highlighted article by the editor).

20. Chang Soo Kim, Petra Wilder-Smith, Yeh-Chan Ahn, Lih-Huei Liaw, Zhongping Chen*, Young Jik Kwon*. Enhanced detection of early stage oral cancer in vivo by optical coherence tomorgraphy using multi-modal delivery of gold nanoparticles. Journal of Biomedical Optics 14, 034008 (2009).

19. Min Suk ShimYoung Jik Kwon*. Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery. Bioconjugate Chemistry 20, 488-499 (2009).

18. Min Suk ShimYoung Jik Kwon*. Controlled cytoplasmic and nuclear localization of plasmid DNA and siRNA by differentially tailored polyethylenimine. Journal of Controlled Release 133, 206-213 (2009).


17. Young Jik Kwon*, Ching-An Peng. Differential interaction of retroviral vector with target cell: Quantitative effect of cellular receptor, soluble proteoglycan, and cell type on gene delivery efficiency. Tissue Engineering 14, 1497-1506 (2008) (invited paper).

16. In Kap Ko, Assem Ziady, Shwei LuYoung Jik Kwon*. Acid-degradable cationic methacrylamide polymerized in the presence of plasmid DNA as tunable non-viral gene carrier. Biomaterials 29, 3872-3881 (2008).

15. Min Suk ShimYoung Jik Kwon*. Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules 9, 444-455 (2008). (The 2nd most accessed article in the journal for the first quarter of 2008).

14.  Hong Yu*, Young Jik Kwon. Preparation and quantification of pseudotyped retroviral vector. Methods in Molecular Biology 433, 1-16 (2008). (Invited book chapter)

Before UCI (2001-2007)

13. Stephany M. Standley, Ines Mende, Sarah L. Goh, Young Jik Kwon, Tristan Beaudette, Edgar G. Engleman, Jean M. J. Fréchet*. Incorporation of CpG oligonucleotide ligand into protein-loaded particlevaccines promotes antigen-specific CD8 T cell immunity. Bioconjugate Chemistry 18, 77-83 (2007).

12. Young Jik Kwon, Edward James, Nilabh Shastri, Jean M. J. Fréchet*. In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.Proceedings of the National Academy of Sciences in the United States of America 102, 18264-18268 (2005).

11. Young Jik Kwon, Stephany M. Standley, Sarah L. Goh, Jean M. J. Fréchet*. Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles. Journal of Controlled Release 105, 199-212 (2005).

10. Young Jik Kwon, Ching-An Peng*. High-yield retroviral production using temperature modulated two-stage operation. Biotechnology and Bioengineering 90, 365-372 (2005).

9. Young Jik Kwon, Stephany M. Standley, Andrew P. Goodwin, Elizabeth R. Gillies, Jean M. J. Fréchet*. Directed antigen presentation using polymeric microparticulate carriers degradable at lysosomal pH for controlled immune responses. Molecular Pharmaceutics 2, 83-91 (2005).

8. Stephany M. Standley, Young Jik Kwon, Niren Murthy, Jun Kunisawa, Nilabh Shastri, Jean M. J. Fréchet*. Acid-Degradable Particles for protein-based vaccines: Enhanced survival rate for tumor-challenged mice using ovalbumin model. Bioconjugate Chemistry 15, 1281-1288 (2004).

7. Young Jik Kwon, Gene Hung, W. French Anderson, Ching-An Peng, Hong Yu*. Determination of Infectious retrovirus concentration from colony-forming assay with quantitative analysis. Journal of Virology 77, 5712-5720 (2003).

6. Young Jik Kwon, Ching-An Peng*. Evaluation of retroviral production systems using quantitative analysis. Biotechnology Progress 19, 528-537 (2003).

5. Young Jik Kwon, Ching-An Peng*. Calcium-alginate gel bead crosslinked with gelatin as potential microcarrier for anchorage-dependent cell culture. BioTechniques 33, 212-218 (2002) (Selected as a BioSpotlight of the issue).

4. Young Jik Kwon, Ching-An Peng*. Engineering analysis of ex vivo retroviral transduction systems. Annals of Biomedical Engineering 30, 731-742 (2002).

3. Young Jik Kwon, Ching-An Peng*. Transduction rate constant as more reliable index quantifying efficiency of retroviral gene delivery. Biotechnology and Bioengineering 77, 668-677 (2002).

2. Young Jik Kwon, Ching-An Peng*. Impact of cell growth morphology on retroviral transduction: Effect of contact inhibition. Biotechnology Progress 17, 240-246 (2001).

1. Young Jik Kwon, Hong Yu, Ching-An Peng*. Enhanced retroviral transduction of 293 cells cultured on liquid-liquid interface. Biotechnology and Bioengineering 72, 331-338 (2001)